Extrusion/Spheronization is one of the oldest techniques of manufacturing pellets.
The extrusion-spheronization process is comonnly used in the pharmaceutical industry to make uniformly sized spheroids. It is especially useful for making dense granules for controlled-release solid dosage oral forms with a minimum amount of excipients.
The dry, powder active substances and excipients are mixed and kneaded into dough with the help of a liquid as a binder. This dough is then pressed through an extruder. The diameter of the openings in the extrusion plate will determine the strength of the extrusion threads that result.
The ratio of solid to liquid material together with the size of the extruder holes determines the quality of the extrudates. The final drying step will ensure the pellet hardness.
Even if the ball-shaped extrudate is imperfect, the evenness of the surface will still create good conditions for subsequent coating. For many pharmaceutical applications, extruded pellets are achieved in suitable quality if a sufficient portion of microcrystalline cellulose is added.
The UMANG Extrusion/ Spheronization System are a turnkey pellet production plant, which will meet all your pelletization needs. Continuously wet powders pass through a low-shear radial extruder / cone extruder / pressure extruder / basket extruder. The extrusions are fragmented and formed into pellets in the spheronizer.
We have single and twin spheronization options possible in the integrated system, for high throughput systems we recommend single extruder and twin spheronizers with twin bucket assembly for feeding the spheronizers.