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Hot melt twin screw extrusion

Hot melt twin screw extrusion for wax and tonner applications:

Hot melt extrusion is a process of applying heat and pressure to melt a polymer and force it through an orifice in a continuous process. The process was developed to produce polymer products of uniform shape and density. It can also be applied in the manufacturing of medical devices and to mix active with polymers to enhance its bioavailability.
Hot melt extrusion is carried out using extruders that transport the material down the barrel.

The extruder consists of four different parts:

  • An opening through which material enters the barrel
  • A conveying section which comprises the barrel and the screw that transport and mix the material
  • A die for shaping the material as it leaves the extruder.
  • Other equipment for cooling, cutting and collecting the finished product

Twin screw extruders are used for melt mixing polymers with additional excipients and for devolatization.

In Production of pharmaceutical formulations, twin extruders are preferred because the rotation of the intermeshing screws provides better mixing to produce a homogenous solid mass containing finely dispersed API particles or a solid solution of API in polymer. This improves the dissolution rate and bioavailability of poorly water soluble API formulations.

Our Hot Melt Twin-screw Extruder allows rapid process development with minimal use of expensive ingredients for critical process parameters. They reduce space requirements, allow for controllable, consistent processing and are suitable for process analysis. The Hot Melt Twin-screw Extruder also minimizes scale-up risk and lowers product changeover time.

The Hot Melt Twin-screw Extruder is compatible with a wide range of GMP standards.


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