Spheronizers is the new pelletization range that builds on the proven Umang technology and its benefits. The design of the plate and the gap between the bowl and the chequered plate ensures that process and validation wise there is no difference to thepelletization process. This unique design of chequered plate, the chequered design of the plate cuts the extrudes in round pharma pellets making it an ideal Spheronizers machine.
The outstanding feature of the Spheronizers is the integrated and CIP optimized design. Connections, cabling and supplies are completely integrated, covered and sealed so the outside of the machine is smooth and very easy to clean. The innovative discharge valve design and optimized seals inside the bowl allow for CIP. As a result of this the our Spheronizers is highly flexible, quick product changeover increases productivity and cost effectiveness.
The Spheronizers ranges from 100 gms / batch capacity to 100 Kgs./ batch featuring through the wall design and completely cleanable designs, allowing operation with platform and dust-free discharging via a linked mill directly into an IBC. The Spheronizers can be stand-alone or linked to a extrurder like a die roller extruder, screw extruder, basket extruder or a mixer extruder giving a highly dense and uniform pellet. A Fluid Bed Wurster can also be a part an integrated system.
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Technical Specifications for Spheronizer:
| Model | Spheronizers 250 | Spheronizers 380 | Spheronizers 500 | Spheronizers 700 | Spheronizers 900 |
| Batch Cap./Kgs. | 0.2 -1 kg / hr | 1-3 kgs/ hr | 3-7 kgs/hr | 5-15 kgs/ hr | 20-40 kgs / hr |
The Umang Pharmaceutech Test Station is located in Vasai, THane, conveniently located very close to Mumbai airport, only forty five minutes from Mumbai International Airport. The Test Station's purpose is to assist our Pharmaceutical and Biopharmaceutical Industry customers with feasibility testing of their products on our equipment, and to be a partner with them in the process development as they move forward from the Research and Development stages to clinical production, and eventually into full-scale Manufacturing.
The station combines decades of design and development know-how in the pharmaceutical industry with the very latest in processing equipment to provide you with a unique opportunity for feasibility, development, and small-scale manufacturing of pharmaceutical products.
Your needs are critical and individual. The UMANG Pharmaceutical Test Station has been designed to meet those needs.
Our expertise in formulation development extends to the development of all conventional dosage forms. Our strategic alliances broaden the scope to consider many Novel Drug Delivery Systems (NDDS), including transdermal & liposomal delivery systems. We consider multiple approaches to improve the bioavailability of drugs. We have expertise in improving delivery of poorly soluble/ permeable drugs and the capability to screen potentially innovative drugs based on pharmacokinetic properties. We possess pelletization, drug-layering, particle-coating and other technologies to achieve extended release profiles for tablets or capsules.
Our analytical development services include assay and RS method development and validation, dissolution method development and validation, stability studies as per ICH guidelines, polymorphic form characterization (DSC/TGA/XRD/Microscopy), cleaning validation studies and HPLC to UPLC method conversions.
What is the lowest particle size which can be processed in a Spheronizer?
200-300 microns
What is the gap between the drum and chequered plate?
0.2 mm .
Can we minimize heat generation during spheronization?
Yes, by a water jacket.
Will the Spheronizer contaminate by product change over ?
The Spheronizer is built completely CGMP which reduces risk of contamination.
What is the rotational speed of a Spheronizer?
Large Spheronizer run at a lesser speed of 300-750 RPM and small batch machine at 1500-3000 RPM .
Can the Spheronizer make porous pellets?
Yes
Can a Spheronizer be used to make micro pellets / MUPS ?
Yes due to less gap.
Can a Spheronizer be coupled with a twin screw extruder to give hot melt pellets ?
Yes , a jacketed spheronizer.
Will the process heat up my material excessively?
Just for a flash time.
Do you offer wash down for SS designs ?
Yes
